Healing & Repair MOD

Session 5Healing and Repair
Objectives
Understanding the terms:
a-Resolution,
b-fibrous repair,
c-Regeneration,
d-Labile, stable and permanent cells.
Description and discussion of:
a- Healing of a clean incised skin wound.
b- Healing of large skin defect
c- Control mechanism in the above process.
d- Structure and function of type 1 collagen
e- Factors influencing the efficacy of healing and repair.
Describing special aspect of healing and repair in various tissues including:
Cardiac muscle
Bone
Liver
Peripheral nerve
Repair of damaged tissue occur by 2 types of reactions: 1- Regeneration: Proliferation of the residual cells and maturation of tissue stem cells. Normal structure is restored
2- Connective tissue deposition: Response to injury involving both regeneration and scar formation (fibrosis). Normal structure is permanently altered.
Cells proliferate during repair . 1-Remannts cell of injured organ: to restore normal structure and function .

2- Vascular endothelial cells: create new blood vessels.

3- Fibroblast: source of fibrosis in scar formation