thyroid

33 years old female presented with diffuse thyroid enlargement , weight gain, joint pain , bready cardia, slow speech , Buffy eyes, constipation
HASHIMOTO THYROIDITIS
Hashimoto thyroiditis (or chronic lymphocytic thyroiditis) is the most common cause of hypothyroidism It is characterized by gradual thyroid failure because of autoimmune destruction of the thyroid gland.
Pathogenesis.
The Hashimoto thyroiditis is an autoimmune disease in which the immune system reacts against a variety overriding feature of Hashimoto thyroiditis is progressive depletion of thyroid epithelial cells (thyrocytes)
which are gradually replaced by mononuclear cell infiltration and fibrosis. Multiple immunologic mechanisms may contribute to the death of thyrocytes The thyroid is often diffusely enlarged
, although more localized enlargement may be seen in some cases. Microscopic examination reveals extensive infiltration of the parenchyma by a mononuclear inflammatory infiltrate containing small lymphocytes, plasma cells, The thyroid follicles are atrophic and well-developed germinal centers